Harald kandolf biography of albert
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Clinical guidelines
European S3-Guidelines on the systemic treatment of psoriasis vulgaris
D Pathirana, AD Ormerod, P Saiag, C Smith, PI Spuls, A Nast, J Barker, JD Bos, G-R Burmester, S Chimenti, L Dubertret, B Eberlein, R Erdmann, J Ferguson, G Girolomoni, P Gisondi, A Giunta, C Griffiths, H Hönigsmann, M Hussain, R Jobling, S-L Karvonen, L Kemeny, inom Kopp, C Leonardi, M Maccarone, A Menter, U Mrowietz, L Naldi, T Nijsten, J-P Ortonne, H-D Orzechowski, T Rantanen, K Reich, N Reytan, H Richards, HB Thio, P Van dem Kerkhof and B Rzany
Volume 23, Issue S2, August – 2009, Pages 1–70
Commentary on the europeisk S3-Guidelines on the systemic treatment of Psoriasis
A Giannetti
Volume 24, Issue 3, March – 2010, Pages 368
Clinical practice guideline for an integrated approach to comorbidity in patients with psoriasis
E. Daudén, S. Castañeda, C. Suárez, J. García-Campayo, A.J. Blasco, M.D. Aguilar, C. Ferrándiz, L. Puig, J.L. Sánchez-Carazo and on behalf of the Working Group
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A life for medical virology (1924 - 2021). On 1 May 2021, Prof. Dr. med. Gisela Enders, a pioneer of medical virology, passed away in her home town of Stuttgart. We are filled with grief and respect and look back on her life's work, which at the same time provides an insight into the development of virology in Germany as an independent subject in science, university teaching and medicine.
Mrs Enders was born Gisela Ruckle on 25 May 1924 in Stuttgart and grew up as a true Swabian: she was hard-working, inventive, shrewd, persistent, caring and assertive. Studying medicine was her great desire. Independently, she transferred to a grammar school at the age of 15 and, after graduating from high school, studied medicine in Munich and Tübingen from 1943 to 1949 (doctorate in 1953). Under wartime conditions she did nursing service in a military hospital. After various intermediate stations as a guest assistant at the University Children's Hospital in Cambridge and as a scientific assistan
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Abstract
Cyclophilins are a group of highly conserved cytosolic enzymes that have a peptidylprolyl cis/trans isomerase activity. Cyclophilin A (CyPA) can be secreted in the extracellular space by inflammatory cells and upon cell death. The presence of CyPA in patients with non-ischemic cardiomyopathy is associated with poor clinical prognosis. Here, we investigated the inhibition of extracellular CyPA in a mouse model of troponin I-induced autoimmune myocarditis using the strictly extracellular CyPA-inhibitor MM284. Since A/J mice develop severe inflammation and fibrosis after immunization with murine cardiac troponin I (mcTn I), we used this model to analyze the effects of an extracellular CyPA inhibition. As extracellular CyPA-inhibitor we used the recently described CsA-derivate MM284. In vitro studies confirmed that MM284 inhibits CyPA-induced monocytic migration and adhesion. A/J mice immunized with mcTnI were treated with MM284 or vehicle every second day. After 28 days, we